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Scientists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Medicine 3 - Rheumatology and Immunology, headed by Prof. Dr. Georg Schett, have now decrypted a molecular network that controls these processes and could in future provide a new way to treat organ scarring.
Amiram Goldblum and his team at the Hebrew University of Jerusalem's Institute for Drug Research have discovered 27 new molecules. These molecules all activate a special protein called PPAR-delta and have the potential to treat fatty liver disease, obesity, diabetic nephrotoxicity, and to heal wounds.
Growth factors are ligands that play important roles in the body - they are responsible for tissue regeneration, wound healing, and the maintenance and growth of cells.
Researchers have now successfully created perfect blood vessels in the labs and this may be a huge step in benefitting people with diabetes and other conditions. The report of the procedure appears in a study titled, “Human blood vessel organoids as a model of diabetic vasculopathy,” published in the latest issue of the journal Nature.
For the first time, researchers have successfully cultivated “vascular organoids” in a petri dish that perfectly mimic real human blood vessels.
As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell.
The incidence of some neurological diseases--especially those related to aging, such as Alzheimer's and Parkinson's diseases--is increasing
In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building.